5/1/2023 0 Comments Thebrain 11 crack![]() We also looked at how the neurons adapt when the environment changes. JC: We applied the CRACK platform to study a specific part of the cortex involved with our perception of touch. We looked at how the different neurons from the catalog process information and talk to other neurons when an animal touches objects in their environment. How did you apply this technology within your study? Our CRACK technology will pave the way for a “catalog 2.0,” allowing researchers to collect both molecular and functional information about all of the cells in the brain. This is why we call it Comprehensive Readout of Activity and Cell type Mar Kers, or CRACK (ie. It allows us to hone in and study the function of the cells in the catalog in a comprehensive manner. The technology that my research team developed leverages this new information from the catalog, and adds the next layer of information, which is the activity patterns of the cells. The catalog only describes the molecular composition of the neurons but it doesn’t necessarily say anything about the function of the neurons or the computations they perform. This is part of a collective effort by several teams across multiple institutions. JC: Our collaborators from the Allen Institute for Brain Science had a goal of creating a “ neuron catalog ” by generating a census of all of the types of cells in the brain. To really understand how the brain operates, we need to deconstruct the brain down to its individual components and then start asking how these components interact during behavior.Ĭan you please explain the first-of-its-kind “neuron catalog” technology that contributed to this study – and its impact? There are hundreds of thousands of different types of neurons – serving different functions and carrying out different computations. That complexity is partially defined by the fact that billions of the neurons in the brain are not all the same. The brain is the most complex organ in the body. Jerry Chen (JC): Our lab is interested in studying the neural basis for perception and cognition. What did you aim to study with your research? What made you want to examine this issue? In this interview, we speak to Chen about his study’s aims, findings and implications. Chen’s findings could have important ramifications not only for our understanding of how our brains are wired, but for our ability to offer therapies for disorders where sensory processing is disrupted, such as autism spectrum disorder (ASD). Chen has published new research in Science that uncovers how the mouse brain processes the sense of touch at a cellular level using a technology called Comprehensive Readout of Activity and Cell type Markers, or CRACK. How do our genes, cells and electrical impulses come together to decode the world around us?Īt Boston University’s College of Arts & Sciences, Assistant Professor of biology Jerry Chen is trying to crack this code. We know our brain has layers of complexity rivaling that of our environment but unpicking that intricacy at a cellular level is a mammoth task. Reach out and touch an object around you – it could be hot, cold, sharp soft, rough or smooth – and know that your brain is processing a dizzying array of information in that simple action. They are good kids who can learn to control their emotions and make better choices, no matter the situation.Our world is awash with sensory information. This gentle introduction to emotion regulation will help children realize they are not bad kids who make bad choices. B help him keep his peanut calm, cool, and collected? Once he discovers how his brain works, Diego understands why his body feels out of control when he is angry or overwhelmed. ![]() B, Diego learns that the reason he acts the way he does is because of a peanut-shaped part of his brain called the amygdala. He begins to feel like something is wrong with him and wonders if he is a bad kid. When kids learn how the brain works, they can begin to listen to their bodies and control their emotions.ĭiego doesn’t understand why he always seems to lose his temper and lash out at people. Give Kids the Tools They Need to Control Their EmotionsĪllison Edwards’ How to Crack Your Peanut helps kids understand why they sometimes lose control and make bad decisions.
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